Anti-CrkII Monoclonal Antibody

英文名称	Anti-CrkII Monoclonal Antibody
宿主	Mouse
别名	CRKII;p38
应用	WB
稀释比例	WB 1:1000.
交叉反应	Human
蛋白分子量	34kDa
Gene ID	1398
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2b
免疫原	Purified recombinant human CrkII protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human CrkII protein fragments expressed in E.coli.
Subcellular Locations	Cell membrane Cytoplasm
Swiss Prot	P46108
克隆号	3H7-E5-H8
克隆类型	Monoclonal Antibody
背景资料	This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.